kerafast總代理靶點(diǎn)科技貨號(hào)EB0011單克隆抗體Anti-VSV-M [23H12] Antibody與VSV-M蛋白反應(yīng)。

產(chǎn)品特色：

-與VSV-M蛋白發(fā)生反應(yīng)

-適用于蛋白質(zhì)印跡應(yīng)用

背景介紹：

水皰性口炎病毒（VSV）是一種經(jīng)過充分研究的包膜負(fù)鏈RNA病毒。VSV 基因組編碼 5 種蛋白質(zhì)：N、P、M、G 和 L。G蛋白（糖蛋白）位于病毒粒子表面，負(fù)責(zé)病毒附著和滲透。此外，許多慢靜脈載體是用來自印第安納州血清型的VSV-G假分型的。

水皰性口炎病毒（VSV）是一種經(jīng)過充分研究的包膜負(fù)鏈RNA病毒。VSV 基因組編碼 5 種蛋白質(zhì)：N、P、M、G 和 L。M蛋白（或基質(zhì)蛋白）負(fù)責(zé)結(jié)合核衣殼并將其凝聚成緊密盤繞的螺旋，并將核衣殼與包膜結(jié)合。M蛋白的這種活性使病毒具有彈狀的形狀。除了M蛋白在病毒組裝中的作用外，它還負(fù)責(zé)介導(dǎo)VSV發(fā)病機(jī)制的分子機(jī)制。野生M型蛋白抑制感染細(xì)胞中的宿主基因表達(dá)并抑制抗病毒反應(yīng)。

Background：

Vesicular stomatitis virus (VSV) is a well studied, enveloped, negative-strand RNA virus. The VSV genome encodes for 5 proteins: N, P, M, G, and L. The G protein (glycoprotein) is located at the virion surface and is responsible for virus attachment and penetration. Additionally, many lentivrial vectors are pseudotyped with VSV-G from the Indiana serotype.

Vesicular stomatitis virus (VSV) is a well studied, enveloped, negative-strand RNA virus. The VSV genome encodes for 5 proteins: N, P, M, G, and L. The M protein (or matrix protein) is responsible for binding the nucleocapsid and condenses it into a tightly coiled helix and binds the nucleocapsid to the envelope. This activity of the M protein is what gives the virus its bullet like shape. In addition to M protein's role in virus assembly, it is also responsible for mediating molecular mechanisms of VSV pathogenesis. Wild-type M protein surpresses host gene expression in infected cells and inhibits antiviral responses.

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