小鼠急性損傷模型，比較常見的是LPS誘導的急性腹膜炎小鼠模型；ConA 誘導的肝炎模型和盲腸結(jié)扎穿刺（CLP）誘導的敗血癥小鼠模型。如何在急性模型中清除巨噬細胞，可以參考如下這篇文獻。

論文信息：

論文題目：Glycogen metabolism regulates macrophage-mediated acute inflammatory responses

期刊名稱：Nature Communications

時間期卷：11, Article number: 1769(2020)

在線時間：2020年4月14日

DOI： doi.org/10.1038/s41467-020-15636-8

產(chǎn)品信息：

貨號：C-005

規(guī)格：5ml

品牌：Liposoma

產(chǎn)地：荷蘭

名稱：Clodronate Liposomes

辦事處：Target Technology(靶點科技)

Clodronate Liposomes氯膦酸鹽脂質(zhì)體清除巨噬細胞介導的急性炎癥模型 ，荷蘭Liposoma巨噬細胞清除劑ClodronateLiposomes見刊于Nature Communications：糖原代謝調(diào)節(jié)巨噬細胞介導的急性炎癥反應。

氯膦酸二鈉脂質(zhì)體ClodronateLiposomes清除三種急性損傷模型巨噬細胞解決方案：

Animal studies

In the LPS-induced acute peritonitis mouse model, C57BL/6J mice were treated with GPI (10?μg?g?1, i.p., 12 and 4?h before LPS injection), 6AN (15?μg?g?1, i.p., 12 and 4?h before LPS injection) or clodronate liposomes (Clod, 10?μL?g?1, i.p., 36 and 4?h before- and 36?h after- LPS injection), followed by i.p. injection of 20?μg?g?1 body weight LPS. In the ConA-induced hepatitis model, C57BL/6J mice were treated with GPI (10?μg?g?1, i.v., 12 and 4?h before ConA injection), 6AN (15?μg?g?1, i.v., 12 and 4?h before ConA injection) or clodronate liposomes (Clod, 10?μL?g?1, i.p., 36 and 4?h before- and 36?h after- ConA injection), followed by i.v. injection of 15?μg?g?1 body weight ConA. In the cecal ligation and puncture (CLP)-induced sepsis mouse model, C57BL/6J mice were treated with GPI (10?μg?g?1, i.p., 12 and 4?h before CLP procedure), 6AN (15?μg?g?1, i.p., 12 and 4?h before CLP procedure) or clodronate liposomes (10?μL?g?1, i.p., 36 and 4?h before- and 36?h after- CLP procedure), followed by CLP procedure.